Fringe follows the exploits of FBI Special Agent Olivia Dunham, scientist Walter Bishop, and his son Peter as they investigate aspects of fringe science telepathy levitation invisibility, reanimation, genetic mutation psycho kinesis, teleportation, nanotechnology, artificial intelligence, precognition, dark matter cybernetics, suspended animation, transmogrification, etc). All over the world, a series of apparent experiments collectively referred to as "the Pattern" (e.g., a newborn baby who rapidly ages and dies within a few hours, a bus full of passengers trapped in a strange substance like mosquitoes in amber) are occurring for reasons unknown. Olivia, Peter, and Walter are in charge of investigating these strange events to determine their source. Connected to the Pattern is Massive Dynamic, a leading global research company that holds the patents for a number of new and important technologies. Throughout the first half of the first season, Mitchell Loeb, a rogue FBI agent, orchestrates some of these events as part of a larger plan to break a man out of prison and kidnap Olivia.
Unlike his other series, Lost, J.J. Abrams promises the series' story arc will be easier to follow and more accessible for those who skip the odd show. In an interview first published in September 2008, Abrams said: "Lost has garnered a certain reputation for being a very complicated show and one that you have to watch every episode. Fringe is in many ways an experiment for us, which is, we believe it is possible to do a show that does have an overall story and end game, which Fringe absolutely does… We can do a show that has that, so that there's a direction the show is going and there's an ultimate story that's being told, but also a show that you don't have to watch episodes one, two and three to tune into episode four."[